Cargando…

Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling

High endothelial venule protein/SPARC-like 1 (hevin/Sparcl1) is an astrocyte-secreted protein that regulates synapse formation in the brain. Here we show that astrocytic hevin signaling plays a critical role in maintaining chronic pain. Compared with WT mice, hevin-null mice exhibited normal mechani...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Gang, Xu, Jing, Luo, Hao, Luo, Xin, Singh, Sandeep K., Ramirez, Juan J., James, Michael L., Mathew, Joseph P., Berger, Miles, Eroglu, Cagla, Ji, Ru-Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746899/ https://www.ncbi.nlm.nih.gov/pubmed/36256481 http://dx.doi.org/10.1172/jci.insight.161028

Ejemplares similares

Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability
por: Taketomi, Takumi, et al.
Publicado: (2022)

Mutations in Hevin/Sparcl1 and risk of autism spectrum disorder
por: Taketomi, Takumi, et al.
Publicado: (2022)

Altered Developmental Expression of the Astrocyte-Secreted Factors Hevin and SPARC in the Fragile X Mouse Model
por: Wallingford, Jessica, et al.
Publicado: (2017)

Sparcl1 and Atherosclerosis
por: Cheng, Xu, et al.
Publicado: (2023)

The Matricellular Protein Hevin Is Involved in Alcohol Use Disorder
por: Nuñez-delMoral, Amaia, et al.
Publicado: (2023)

Disadvantages of a SPARCling defense
por: Bashyam, Hema
Publicado: (2008)

Hevin Plays a Pivotal Role in Corneal Wound Healing
por: Chaurasia, Shyam S., et al.
Publicado: (2013)

Modulation of SPARC/Hevin Proteins in Alzheimer’s Disease Brain Injury
por: Strunz, Maximilian, et al.
Publicado: (2019)

Astrocytic Neuroligins Control Astrocyte Morphogenesis and Synaptogenesis
por: Stogsdill, Jeff A., et al.
Publicado: (2017)

Correction: Hevin Plays a Pivotal Role in Corneal Wound Healing
por: Chaurasia, Shyam S., et al.
Publicado: (2014)

The role of astrocyte-secreted matricellular proteins in central nervous system development and function
por: Eroglu, Cagla
Publicado: (2009)

Sparcle: assigning transcripts to cells in multiplexed images
por: Prabhakaran, Sandhya
Publicado: (2022)

Hevin is down-regulated in many cancers and is a negative regulator of cell growth and proliferation
por: Claeskens, A, et al.
Publicado: (2000)

Atorvastatin in stroke: a review of SPARCL and subgroup analysis
por: Huisa, Branko N, et al.
Publicado: (2010)

Prognostic value of SPARCL1 in patients with colorectal cancer
por: Han, Wei, et al.
Publicado: (2018)

Effects of SPARCL1 on the proliferation and differentiation of sheep preadipocytes
por: Xiao, Cheng, et al.
Publicado: (2021)

Associations of tumor suppressor SPARCL1 with cancer progression and prognosis
por: Li, Ting, et al.
Publicado: (2017)

δ-Catenin controls astrocyte morphogenesis via layer-specific astrocyte–neuron cadherin interactions
por: Tan, Christabel Xin, et al.
Publicado: (2023)

The role of astrocyte structural plasticity in regulating neural circuit function and behavior
por: Lawal, Oluwadamilola, et al.
Publicado: (2022)

Methylation of SPARCL1 Is Associated with Oncologic Outcome of Advanced Upper Urinary Tract Urothelial Carcinoma
por: Luo, Hao-Lun, et al.
Publicado: (2019)

CDD/SPARCLE: functional classification of proteins via subfamily domain architectures
por: Marchler-Bauer, Aron, et al.
Publicado: (2017)

Immunological role and prognostic value of SPARCL1 in pan-cancer analysis
por: He, Kangwei, et al.
Publicado: (2022)

NMDA Receptors in Astrocytes: In Search for Roles in Neurotransmission and Astrocytic Homeostasis
por: Skowrońska, Katarzyna, et al.
Publicado: (2019)

GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes
por: Bindu, Dhanesh Sivadasan, et al.
Publicado: (2023)

Building bridges with astrocytes for spinal cord repair
por: Miller, Robert H
Publicado: (2006)

Astrocytes contribute to pain gating in the spinal cord
por: Xu, Qian, et al.
Publicado: (2021)

Astrocyte transplantation for repairing the injured spinal cord
por: Zheng, Xiaolong, et al.
Publicado: (2022)

Acute post-injury blockade of α2δ−1 calcium channel subunits prevents pathological autonomic plasticity after spinal cord injury
por: Brennan, Faith H., et al.
Publicado: (2021)

Characterisation of the Expression of NMDA Receptors in Human Astrocytes
por: Lee, Ming-Chak, et al.
Publicado: (2010)

PATHOLOGY OF THE SPINAL CORD
Publicado: (1978)

Astrocyte-to-neuron conversion induced by spinal cord injury
por: Noristani, Harun Najib, et al.
Publicado: (2016)

Response of Astrocyte Subpopulations Following Spinal Cord Injury
por: Allahyari, R. Vivian, et al.
Publicado: (2022)

In vivo astrocyte reprogramming following spinal cord injury
por: Gerber, Yannick N., et al.
Publicado: (2023)

Expression of AMPA and NMDA receptor subunits in the cervical spinal cord of wobbler mice
por: Bigini, Paolo, et al.
Publicado: (2006)

Modulation of GABAergic Synaptic Transmission by NMDA Receptors in the Dorsal Horn of the Spinal Cord
por: Leonardon, Benjamin, et al.
Publicado: (2022)

Species-, organ- and cell-type-dependent expression of SPARCL1 in human and mouse tissues
por: Klingler, Anika, et al.
Publicado: (2020)

Quality of Life in Young Adults With Cerebral Palsy: A Longitudinal Analysis of the SPARCLE Study
por: Vidart d'Egurbide Bagazgoïtia, Nicolas, et al.
Publicado: (2021)

SPARCL1 Is a Novel Prognostic Biomarker and Correlates with Tumor Microenvironment in Colorectal Cancer
por: Zhang, Hai-Ping, et al.
Publicado: (2022)

Bidirectional modulation between infiltrating CD3(+) T-lymphocytes and astrocytes in the spinal cord drives the development of allodynia in monoarthritic rats
por: Zhou, Ya-Lan, et al.
Publicado: (2018)

In vivo conversion of astrocytes to neurons in the injured adult spinal cord
por: Su, Zhida, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_jo45s5g99tujnr6nhis2lj9ivh