Muscle velocity recovery cycles as pharmacodynamic biomarker: Effects of mexiletine in a randomized double‐blind placebo‐controlled cross‐over study

Measuring muscle velocity recovery cycles (MVRCs) is a method to obtain information on muscle cell excitability, independent of neuromuscular transmission. The goal was to validate MVRC as a pharmacodynamic (PD) biomarker for drugs targeting muscle excitability. As proof‐of‐concept, sensitivity of M...

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Detalles Bibliográficos
Autores principales: Ruijs, Titia Q., Koopmans, Ingrid W., de Kam, Marieke L., Tannemaat, Martijn R., Groeneveld, Geert Jan, Heuberger, Jules A. A. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747120/
https://www.ncbi.nlm.nih.gov/pubmed/36281627
http://dx.doi.org/10.1111/cts.13418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747120/
https://www.ncbi.nlm.nih.gov/pubmed/36281627
http://dx.doi.org/10.1111/cts.13418

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