State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides

The G protein-coupled receptor cascade leading to production of the second messenger cAMP is replete with pharmacologically targetable proteins, with the exception of the Gα subunit, Gαs. GTPases remain largely undruggable given the difficulty of displacing high-affinity guanine nucleotides and the...

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Detalles Bibliográficos
Autores principales: Dai, Shizhong A., Hu, Qi, Gao, Rong, Blythe, Emily E., Touhara, Kouki K., Peacock, Hayden, Zhang, Ziyang, von Zastrow, Mark, Suga, Hiroaki, Shokat, Kevan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747239/
https://www.ncbi.nlm.nih.gov/pubmed/36170854
http://dx.doi.org/10.1016/j.cell.2022.09.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747239/
https://www.ncbi.nlm.nih.gov/pubmed/36170854
http://dx.doi.org/10.1016/j.cell.2022.09.019

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