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State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides
The G protein-coupled receptor cascade leading to production of the second messenger cAMP is replete with pharmacologically targetable proteins, with the exception of the Gα subunit, Gαs. GTPases remain largely undruggable given the difficulty of displacing high-affinity guanine nucleotides and the...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747239/ https://www.ncbi.nlm.nih.gov/pubmed/36170854 http://dx.doi.org/10.1016/j.cell.2022.09.019 |