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Interleukin-27 impairs BCG antigen clearance and T cell stimulatory potential by neonatal dendritic cells

Bacille Calmette Guérin (BCG) is a live-attenuated vaccine for protection against Mycobacterium tuberculosis. Despite high disease protection in infancy and early childhood, it generates poor long-term protection against pulmonary tuberculosis. We hypothesized that the unique immune profile that inc...

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Detalles Bibliográficos
Autores principales: Bradford, Shelby D., Witt, Michelle R., Povroznik, Jessica M., Robinson, Cory M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747568/
https://www.ncbi.nlm.nih.gov/pubmed/36530844
http://dx.doi.org/10.1016/j.crmicr.2022.100176