The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection

Influenza remains a major public health challenge, as the viral infection activates multiple biological networks linked to altered host innate immunity. Following infection, IFN-λ, a ligand crucial for the resolution of viral infections, is known to bind to its cognate receptor, IFNLR1, in lung epit...

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Detalles Bibliográficos
Autores principales: Tsai, MuChun, Osman, Wissam, Adair, Jessica, ElMergawy, Rabab, Chafin, Lexie, Johns, Finny, Farkas, Daniela, Elhance, Ajit, Londino, James, Mallampalli, Rama K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747586/
https://www.ncbi.nlm.nih.gov/pubmed/36379255
http://dx.doi.org/10.1016/j.jbc.2022.102698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747586/
https://www.ncbi.nlm.nih.gov/pubmed/36379255
http://dx.doi.org/10.1016/j.jbc.2022.102698

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