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ABCA1 and cholesterol transfer protein Aster-A promote an asymmetric cholesterol distribution in the plasma membrane

Cholesterol is a major and essential component of the mammalian cell plasma membrane (PM), and the loss of cholesterol homeostasis leads to various pathologies. Cellular cholesterol uptake and synthesis are regulated by a cholesterol sensor in the endoplasmic reticulum (ER). However, it remains uncl...

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Detalles Bibliográficos
Autores principales: Ogasawara, Fumihiko, Ueda, Kazumitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747601/
https://www.ncbi.nlm.nih.gov/pubmed/36395885
http://dx.doi.org/10.1016/j.jbc.2022.102702