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Results from a phase 1, randomized, double-blind, multiple ascending dose study characterizing the pharmacokinetics and demonstrating the safety and selectivity of the aldosterone synthase inhibitor baxdrostat in healthy volunteers

Baxdrostat is a selective inhibitor of aldosterone synthase designed for the treatment of disorders associated with elevated aldosterone. This study evaluated the safety, pharmacokinetics, and pharmacodynamics of multiple ascending doses of baxdrostat in healthy volunteers. Subjects were randomized...

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Detalles Bibliográficos
Autores principales: Freeman, Mason W., Bond, Mary, Murphy, Brian, Hui, James, Isaacsohn, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747611/
https://www.ncbi.nlm.nih.gov/pubmed/36266539
http://dx.doi.org/10.1038/s41440-022-01070-4