PfATP4 inhibitors in the Medicines for Malaria Venture Malaria Box and Pathogen Box block the schizont-to-ring transition by inhibiting egress rather than invasion

The cation efflux pump Plasmodium falciparum ATPase 4 (PfATP4) maintains Na(+) homeostasis in malaria parasites and has been implicated in the mechanism of action of many structurally diverse antimalarial agents, including >7% of the antimalarial compounds in the Medicines for Malaria Venture’s ‘...

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Detalles Bibliográficos
Autores principales: Barnes, Claudia B. G., Dans, Madeline G., Jonsdottir, Thorey K., Crabb, Brendan S., Gilson, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747762/
https://www.ncbi.nlm.nih.gov/pubmed/36530423
http://dx.doi.org/10.3389/fcimb.2022.1060202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747762/
https://www.ncbi.nlm.nih.gov/pubmed/36530423
http://dx.doi.org/10.3389/fcimb.2022.1060202

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