BET protein inhibition sensitizes glioblastoma cells to temozolomide treatment by attenuating MGMT expression

Bromodomain and extra-terminal tail (BET) proteins have been identified as potential epigenetic targets in cancer, including glioblastoma. These epigenetic modifiers link the histone code to gene transcription that can be disrupted with small molecule BET inhibitors (BETi). With the aim of developin...

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Detalles Bibliográficos
Autores principales: Tancredi, Alessandro, Gusyatiner, Olga, Bady, Pierre, Buri, Michelle C., Lomazzi, Rémy, Chiesi, Davide, Messerer, Mahmoud, Hegi, Monika E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747918/
https://www.ncbi.nlm.nih.gov/pubmed/36513631
http://dx.doi.org/10.1038/s41419-022-05497-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747918/
https://www.ncbi.nlm.nih.gov/pubmed/36513631
http://dx.doi.org/10.1038/s41419-022-05497-y

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