Upper gut heat shock proteins HSP70 and GRP78 promote insulin resistance, hyperglycemia, and non-alcoholic steatohepatitis

A high-fat diet increases the risk of insulin resistance, type-2 diabetes, and non-alcoholic steato-hepatitis. Here we identified two heat-shock proteins, Heat-Shock-Protein70 and Glucose-Regulated Protein78, which are increased in the jejunum of rats on a high-fat diet. We demonstrated a causal lin...

Descripción completa

Detalles Bibliográficos
Autores principales: Angelini, Giulia, Castagneto-Gissey, Lidia, Salinari, Serenella, Bertuzzi, Alessandro, Anello, Danila, Pradhan, Meenakshi, Zschätzsch, Marlen, Ritter, Paul, Le Roux, Carel W., Rubino, Francesco, Basso, Nicola, Casella, Giovanni, Bornstein, Stefan R., Tremaroli, Valentina, Mingrone, Geltrude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748124/
https://www.ncbi.nlm.nih.gov/pubmed/36513656
http://dx.doi.org/10.1038/s41467-022-35310-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748124/
https://www.ncbi.nlm.nih.gov/pubmed/36513656
http://dx.doi.org/10.1038/s41467-022-35310-5

Ejemplares similares