The voltage-sensing domain of a hERG1 mutant is a cation-selective channel

A cationic leak current known as an “omega current” may arise from mutations of the first charged residue in the S4 of the voltage sensor domains of sodium and potassium voltage-gated channels. The voltage-sensing domains (VSDs) in these mutated channels act as pores allowing nonspecific passage of...

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Detalles Bibliográficos
Autores principales: Kudaibergenova, Meruyert, Guo, Jiqing, Khan, Hanif M., Lees-Miller, James, Mousaei, Mahdi, Miranda, Williams, Ngo, Van A., Noskov, Sergei Yu, Tieleman, D. Peter, Duff, Henry J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748372/
https://www.ncbi.nlm.nih.gov/pubmed/36815709
http://dx.doi.org/10.1016/j.bpj.2022.10.032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748372/
https://www.ncbi.nlm.nih.gov/pubmed/36815709
http://dx.doi.org/10.1016/j.bpj.2022.10.032

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