Association between high-dose methotrexate-induced toxicity and polymorphisms within methotrexate pathway genes in acute lymphoblastic leukemia

Methotrexate (MTX) is a folic acid antagonist, the mechanism of action is to inhibit DNA synthesis, repair and cell proliferation by decreasing the activities of several folate-dependent enzymes. It is widely used as a chemotherapy drug for children and adults with malignant tumors. High-dose methot...

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Detalles Bibliográficos
Autores principales: Xu, Meng, Wu, Shuangshuang, Wang, Yue, Zhao, Yundong, Wang, Ximin, Wei, Changhong, Liu, Xueying, Hao, Feng, Hu, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748425/
https://www.ncbi.nlm.nih.gov/pubmed/36532750
http://dx.doi.org/10.3389/fphar.2022.1003812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748425/
https://www.ncbi.nlm.nih.gov/pubmed/36532750
http://dx.doi.org/10.3389/fphar.2022.1003812

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