Synthesis and bioactivity of readily hydrolysable novel cationic lipids for potential lung delivery application of mRNAs

Lipid nanoparticles (LNPs) mediated mRNA delivery has gained prominence due to the success of mRNA vaccines against Covid-19, without which it would not have been possible. However, there is little clinical validation of this technology for other mRNA-based therapeutic approaches. Systemic administr...

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Detalles Bibliográficos
Autores principales: Pei, Yihua, Bao, Yanjie, Sacchetti, Cristiano, Brady, Juthamart, Gillard, Kyra, Yu, Hailong, Roberts, Scott, Rajappan, Kumar, Tanis, Steven P., Perez-Garcia, Carlos G., Chivukula, Padmanabh, Karmali, Priya P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749011/
https://www.ncbi.nlm.nih.gov/pubmed/35122738
http://dx.doi.org/10.1016/j.chemphyslip.2022.105178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749011/
https://www.ncbi.nlm.nih.gov/pubmed/35122738
http://dx.doi.org/10.1016/j.chemphyslip.2022.105178

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