Unraveling the Abnormal Molecular Mechanism of Suicide Inhibition of Cytochrome P450 3A4

[Image: see text] Suicide inhibition of the CYP3A4 enzyme by a drug inactivates the enzyme in the drug biotransformation process and often shows safety concerns about the drug. Despite extensive experimental studies, the abnormal molecular mechanism of a suicide inhibitor that forms a covalent bond...

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Detalles Bibliográficos
Autores principales: Zhou, Yang, Li, Junhao, Baryshnikov, Glib, Tu, Yaoquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749025/
https://www.ncbi.nlm.nih.gov/pubmed/36457253
http://dx.doi.org/10.1021/acs.jcim.2c01035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749025/
https://www.ncbi.nlm.nih.gov/pubmed/36457253
http://dx.doi.org/10.1021/acs.jcim.2c01035

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