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Unraveling the Abnormal Molecular Mechanism of Suicide Inhibition of Cytochrome P450 3A4
[Image: see text] Suicide inhibition of the CYP3A4 enzyme by a drug inactivates the enzyme in the drug biotransformation process and often shows safety concerns about the drug. Despite extensive experimental studies, the abnormal molecular mechanism of a suicide inhibitor that forms a covalent bond...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749025/ https://www.ncbi.nlm.nih.gov/pubmed/36457253 http://dx.doi.org/10.1021/acs.jcim.2c01035 |