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Granulovacuolar degeneration bodies are independently induced by tau and α-synuclein pathology

BACKGROUND: Granulovacuolar degeneration bodies (GVBs) are intracellular vesicular structures that commonly accompany pathological tau accumulations in neurons of patients with tauopathies. Recently, we developed the first model for GVBs in primary neurons, that requires exogenous tau seeds to elici...

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Detalles Bibliográficos
Autores principales: Jorge-Oliva, Marta, Smits, Jasper F. M., Wiersma, Vera I., Hoozemans, Jeroen J. M., Scheper, Wiep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749177/
https://www.ncbi.nlm.nih.gov/pubmed/36517915
http://dx.doi.org/10.1186/s13195-022-01128-y