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Protein charge parameters that influence stability and cellular internalization of polyelectrolyte complex micelles

Proteins are an important class of biologics, but there are several recurring challenges to address when designing protein-based therapeutics. These challenges include: the propensity of proteins to aggregate during formulation, relatively low loading in traditional hydrophobic delivery vehicles, an...

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Detalles Bibliográficos
Autores principales: Kapelner, Rachel A., Fisher, Rachel S., Elbaum-Garfinkle, Shana, Obermeyer, Allie C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749388/
https://www.ncbi.nlm.nih.gov/pubmed/36545145
http://dx.doi.org/10.1039/d2sc00192f