Tissue- and ethnicity-independent hypervariable DNA methylation states show evidence of establishment in the early human embryo

We analysed DNA methylation data from 30 datasets comprising 3474 individuals, 19 tissues and 8 ethnicities at CpGs covered by the Illumina450K array. We identified 4143 hypervariable CpGs (‘hvCpGs’) with methylation in the top 5% most variable sites across multiple tissues and ethnicities. hvCpG me...

Descripción completa

Detalles Bibliográficos
Autores principales: Derakhshan, Maria, Kessler, Noah J, Ishida, Miho, Demetriou, Charalambos, Brucato, Nicolas, Moore, Gudrun E, Fall, Caroline H D, Chandak, Giriraj R, Ricaut, Francois-Xavier, Prentice, Andrew M, Hellenthal, Garrett, Silver, Matt J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749461/
https://www.ncbi.nlm.nih.gov/pubmed/35713545
http://dx.doi.org/10.1093/nar/gkac503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749461/
https://www.ncbi.nlm.nih.gov/pubmed/35713545
http://dx.doi.org/10.1093/nar/gkac503

Ejemplares similares