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Interpretation of Mendelian randomization using a single measure of an exposure that varies over time

BACKGROUND: Mendelian randomization (MR) is a powerful tool through which the causal effects of modifiable exposures on outcomes can be estimated from observational data. Most exposures vary throughout the life course, but MR is commonly applied to one measurement of an exposure (e.g. weight measure...

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Detalles Bibliográficos
Autores principales: Morris, Tim T, Heron, Jon, Sanderson, Eleanor C M, Davey Smith, George, Didelez, Vanessa, Tilling, Kate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749705/
https://www.ncbi.nlm.nih.gov/pubmed/35848950
http://dx.doi.org/10.1093/ije/dyac136