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Oxaliplatin disrupts nucleolar function through biophysical disintegration
Platinum (Pt) compounds such as oxaliplatin are among the most commonly prescribed anti-cancer drugs. Despite their considerable clinical impact, the molecular basis of platinum cytotoxicity and cancer specificity remain unclear. Here we show that oxaliplatin, a backbone for the treatment of colorec...
Autores principales: | Broder Schmidt, H., Jaafar, Zane A., Erik Wulff, B., Rodencal, Jason J., Hong, Kibeom, Aziz-Zanjani, Mohammad O., Jackson, Peter K., Leonetti, Manuel D., Dixon, Scott J., Rohatgi, Rajat, Brandman, Onn |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749789/ https://www.ncbi.nlm.nih.gov/pubmed/36351392 http://dx.doi.org/10.1016/j.celrep.2022.111629 |
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