A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2

Ten-eleven translocation dioxygenases (TETs) are the erasers of 5-methylcytosine (mC), the central epigenetic regulator of mammalian DNA. TETs convert mC to three oxidized derivatives with unique physicochemical properties and inherent regulatory potential, and it initializes active demethylation by...

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Detalles Bibliográficos
Autores principales: Palei, Shubhendu, Weisner, Jörn, Vogt, Melina, Gontla, Rajesh, Buchmuller, Benjamin, Ehrt, Christiane, Grabe, Tobias, Kleinbölting, Silke, Müller, Matthias, Clever, Guido H., Rauh, Daniel, Summerer, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749932/
https://www.ncbi.nlm.nih.gov/pubmed/36545435
http://dx.doi.org/10.1039/d2md00186a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749932/
https://www.ncbi.nlm.nih.gov/pubmed/36545435
http://dx.doi.org/10.1039/d2md00186a

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