Alkyltriphenylphosphonium turns naphthoquinoneimidazoles into potent membrane depolarizers against mycobacteria

Due to its central role in energy generation and bacterial viability, mycobacterial bioenergetics is an attractive therapeutic target for anti-tuberculosis drug discovery. Building upon our work on antimycobacterial dioxonaphthoimidazoliums that were activated by a proximal positive charge and gener...

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Detalles Bibliográficos
Autores principales: Fridianto, Kevin Timothy, Gunawan, Gregory Adrian, Hards, Kiel, Sarathy, Jickky Palmae, Cook, Gregory M., Dick, Thomas, Go, Mei-Lin, Lam, Yulin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749938/
https://www.ncbi.nlm.nih.gov/pubmed/36545436
http://dx.doi.org/10.1039/d2md00251e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749938/
https://www.ncbi.nlm.nih.gov/pubmed/36545436
http://dx.doi.org/10.1039/d2md00251e

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