Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates

Fragment-based drug discovery is now widely adopted for lead generation in the pharmaceutical industry. However, fragment screening collections are often predominantly populated with flat, 2D molecules. Herein, we report the synthesis of piperidine-based 3D fragment building blocks – 20 regio- and d...

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Detalles Bibliográficos
Autores principales: Jones, S. Paul, Firth, James D., Wheldon, Mary C., Atobe, Masakazu, Hubbard, Roderick E., Blakemore, David C., De Fusco, Claudia, Lucas, Simon C. C., Roughley, Stephen D., Vidler, Lewis R., Whatton, Maria Ann, Woolford, Alison J.-A., Wrigley, Gail L., O'Brien, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749955/
https://www.ncbi.nlm.nih.gov/pubmed/36545433
http://dx.doi.org/10.1039/d2md00239f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749955/
https://www.ncbi.nlm.nih.gov/pubmed/36545433
http://dx.doi.org/10.1039/d2md00239f

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