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Bromhexine and its fumarate salt: Crystal structures, Hirshfeld surfaces and dissolution study
Bromhexine is an expectorant drug repurposing as a TMPRSS2 inhibitor, which has also been proposed for potential treatment in COVID-19 infection. Multicomponent crystal strategy has been applied in bromhexine to improve its poor solubility, which limits its bioavailability and efficacy. A new bromhe...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier B.V.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750061/ https://www.ncbi.nlm.nih.gov/pubmed/36536618 http://dx.doi.org/10.1016/j.molstruc.2021.130154 |