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Bromhexine and its fumarate salt: Crystal structures, Hirshfeld surfaces and dissolution study

Bromhexine is an expectorant drug repurposing as a TMPRSS2 inhibitor, which has also been proposed for potential treatment in COVID-19 infection. Multicomponent crystal strategy has been applied in bromhexine to improve its poor solubility, which limits its bioavailability and efficacy. A new bromhe...

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Detalles Bibliográficos
Autores principales: Zhang, Ya-an, Yan, Cui-Min, Sun, Bai-Wang, Wang, Lin-Xuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750061/
https://www.ncbi.nlm.nih.gov/pubmed/36536618
http://dx.doi.org/10.1016/j.molstruc.2021.130154