Membrane curvature sensing and stabilization by the autophagic LC3 lipidation machinery

How the highly curved phagophore membrane is stabilized during autophagy initiation is a major open question in autophagosome biogenesis. Here, we use in vitro reconstitution on membrane nanotubes and molecular dynamics simulations to investigate how core autophagy proteins in the LC3 (Microtubule-a...

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Detalles Bibliográficos
Autores principales: Jensen, Liv E., Rao, Shanlin, Schuschnig, Martina, Cada, A. King, Martens, Sascha, Hummer, Gerhard, Hurley, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750143/
https://www.ncbi.nlm.nih.gov/pubmed/36516251
http://dx.doi.org/10.1126/sciadv.add1436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750143/
https://www.ncbi.nlm.nih.gov/pubmed/36516251
http://dx.doi.org/10.1126/sciadv.add1436

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