Regional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition

Myeloid-derived suppressor cells (MDSCs) expand in response to malignancy and suppress responsiveness to immunotherapy, including checkpoint inhibitors (CPIs). Within the liver, MDSCs have unique immunosuppressive features. While TLR9 agonists have shown promising activities in enhancing CPI respons...

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Detalles Bibliográficos
Autores principales: Ghosh, Chandra C., Heatherton, Kara R., Connell, Kyle P. O’, Alexander, Ian S., Greer, Deborah A., LaPorte, Jason, Guha, Prajna, Cox, Bryan F., Katz, Steven C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750861/
https://www.ncbi.nlm.nih.gov/pubmed/35697801
http://dx.doi.org/10.1038/s41417-022-00484-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750861/
https://www.ncbi.nlm.nih.gov/pubmed/35697801
http://dx.doi.org/10.1038/s41417-022-00484-z

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