Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active

Plants and other organisms, but not insects or vertebrates, express the auxiliary respiratory enzyme alternative oxidase (AOX) that bypasses mitochondrial respiratory complexes III and/or IV when impaired. Persistent expression of AOX from Ciona intestinalis in mammalian models has previously been s...

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Detalles Bibliográficos
Autores principales: Giordano, Luca, Aneja, Manish K., Sommer, Natascha, Alebrahimdehkordi, Nasim, Seraji, Alireza, Weissmann, Norbert, Rudolph, Carsten, Plank, Christian, Jacobs, Howard T., Szibor, Marten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750868/
https://www.ncbi.nlm.nih.gov/pubmed/33664504
http://dx.doi.org/10.1038/s41434-021-00235-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750868/
https://www.ncbi.nlm.nih.gov/pubmed/33664504
http://dx.doi.org/10.1038/s41434-021-00235-z

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