Epigenetically silenced apoptosis-associated tyrosine kinase (AATK) facilitates a decreased expression of Cyclin D1 and WEE1, phosphorylates TP53 and reduces cell proliferation in a kinase-dependent manner

Silencing of the Apoptosis associated Tyrosine Kinase gene (AATK) has been described in cancer. In our study, we specifically investigated the epigenetic inactivation of AATK in pancreatic adenocarcinoma, lower grade glioma, lung, breast, head, and neck cancer. The resulting loss of AATK correlates...

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Detalles Bibliográficos
Autores principales: Woods, Michelle L., Weiss, Astrid, Sokol, Anna M., Graumann, Johannes, Boettger, Thomas, Richter, Antje M., Schermuly, Ralph T., Dammann, Reinhard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750878/
https://www.ncbi.nlm.nih.gov/pubmed/35902728
http://dx.doi.org/10.1038/s41417-022-00513-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750878/
https://www.ncbi.nlm.nih.gov/pubmed/35902728
http://dx.doi.org/10.1038/s41417-022-00513-x

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