RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria

Mitophagy, a mitochondria-specific form of autophagy, removes dysfunctional mitochondria and is hence an essential process contributing to mitochondrial quality control. PTEN-induced kinase 1 (PINK1) and the E3 ubiquitin ligase Parkin are critical molecules involved in stress-induced mitophagy, but...

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Detalles Bibliográficos
Autores principales: Tu, Michelle, Tan, Valerie P., Yu, Justin D., Tripathi, Raghav, Bigham, Zahna, Barlow, Melissa, Smith, Jeffrey M., Brown, Joan Heller, Miyamoto, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751115/
https://www.ncbi.nlm.nih.gov/pubmed/35760846
http://dx.doi.org/10.1038/s41418-022-01032-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751115/
https://www.ncbi.nlm.nih.gov/pubmed/35760846
http://dx.doi.org/10.1038/s41418-022-01032-w

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