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Somatostatin receptor saturation after administration of high peptide amounts of [(177)Lu]Lu-HA-DOTATATE: when enough is enough

BACKGROUND: Receptor saturation during peptide receptor radionuclide therapy (PRRT) could result in altered [(177)Lu]Lu-HA-DOTATATE uptake in tumors and organs. Therefore, receptor expression status and effects of different (unlabeled) administered peptide amounts during PRRT need to be evaluated. T...

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Detalles Bibliográficos
Autores principales: Siebinga, Hinke, Veerman, Chayenne H. A. M., de Wit-van der Veen, Linda, Stokkel, Marcel P. M., Hendrikx, Jeroen J. M. A., Aalbersberg, Else A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751249/
https://www.ncbi.nlm.nih.gov/pubmed/36515683
http://dx.doi.org/10.1186/s13550-022-00946-3