Cargando…

Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis

High-throughput methodologies are the cornerstone of screening approaches to identify novel compounds that regulate immune cell function. To identify novel targeted therapeutics to treat immune disorders and haematological malignancies, there is a need to integrate functional cellular information wi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kong, Isabella Y., Trezise, Stephanie, Light, Amanda, Todorovski, Izabela, Arnau, Gisela Mir, Gadipally, Sreeja, Yoannidis, David, Simpson, Kaylene J., Dong, Xueyi, Whitehead, Lachlan, Tempany, Jessica C., Farchione, Anthony J., Sheikh, Amania A., Groom, Joanna R., Rogers, Kelly L., Herold, Marco J., Bryant, Vanessa L., Ritchie, Matthew E., Willis, Simon N., Johnstone, Ricky W., Hodgkin, Philip D., Nutt, Stephen L., Vervoort, Stephin J., Hawkins, Edwin D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751284/ https://www.ncbi.nlm.nih.gov/pubmed/35831623 http://dx.doi.org/10.1038/s41418-022-01037-5

Ejemplares similares

Whole genome CRISPR screening identifies TOP2B as a potential target for IMiD sensitization in multiple myeloma
por: Costacurta, Matteo, et al.
Publicado: (2020)

Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer
por: Hogg, Simon J., et al.
Publicado: (2022)

Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia
por: So, Joan, et al.
Publicado: (2022)

SUGAR-seq enables simultaneous detection of glycans, epitopes, and the transcriptome in single cells
por: Kearney, Conor J., et al.
Publicado: (2021)

Transcription tipping points for T follicular helper cell and T-helper 1 cell fate commitment
por: Sheikh, Amania A., et al.
Publicado: (2020)

An arrayed CRISPR screen of primary B cells reveals the essential elements of the antibody secretion pathway
por: Trezise, Stephanie, et al.
Publicado: (2023)

Early appearance of germinal center–derived memory B cells and plasma cells in blood after primary immunization
por: Blink, Elizabeth J., et al.
Publicado: (2005)

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis
por: Kelly, Madison J., et al.
Publicado: (2019)

Genome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat
por: Falkenberg, Katrina J, et al.
Publicado: (2014)

Superior properties of CellTrace Yellow™ as a division tracking dye for human and murine lymphocytes
por: Tempany, Jessica C, et al.
Publicado: (2017)

JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias
por: Kim, Sang-Kyu, et al.
Publicado: (2018)

SOX4 Mediates TGF-β-Induced Expression of Mesenchymal Markers during Mammary Cell Epithelial to Mesenchymal Transition
por: Vervoort, Stephin J., et al.
Publicado: (2013)

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity
por: Fan, Zheng, et al.
Publicado: (2020)

Assessing the role of the T-box transcription factor Eomes in B cell differentiation during either Th1 or Th2 cell-biased responses
por: Cooper, Lucy, et al.
Publicado: (2018)

Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection
por: Sheikh, Amania A., et al.
Publicado: (2019)

Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML
por: Salmon, Jessica M., et al.
Publicado: (2022)

Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB
por: Willis, Simon N., et al.
Publicado: (2017)

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1
por: Hogg, Simon J., et al.
Publicado: (2017)

FOXP1 Promotes Embryonic Neural Stem Cell Differentiation by Repressing Jagged1 Expression
por: Braccioli, Luca, et al.
Publicado: (2017)

CXCL11 expressing C57BL/6 mice have intact adaptive immune responses to viral infection
por: Dalit, Lennard, et al.
Publicado: (2022)

C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition
por: Lourenço, Ana Rita, et al.
Publicado: (2020)

Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins
por: Trezise, Stephanie, et al.
Publicado: (2018)

Anatomical and Neuromuscular Determinants of Strength Change in Previously Untrained Men Following Heavy Strength Training
por: Trezise, J., et al.
Publicado: (2019)

Converse Smith-Martin cell cycle kinetics by transformed B lymphocytes
por: Pham, K., et al.
Publicado: (2018)

Prostate MRI and image quality: The radiologist’s perspective
por: Fütterer, Jurgen J., et al.
Publicado: (2023)

Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition
por: Peeters, Janneke G C, et al.
Publicado: (2023)

The effect of relatedness and pack size on territory overlap in African wild dogs
por: Jackson, Craig R., et al.
Publicado: (2017)

Experimental and spontaneous metastasis assays can result in divergence in clonal architecture
por: Serrano, Antonin, et al.
Publicado: (2023)

Genes regulating membrane-associated E-cadherin and proliferation in adenomatous polyposis coli mutant colon cancer cells: High content siRNA screen
por: King, Lauren E., et al.
Publicado: (2020)

Effectiveness and mediators of change of an online CBT intervention for students with adjustment disorder—study protocol for a randomized controlled trial
por: Juszczyk-Kalina, A., et al.
Publicado: (2023)

Visual pigments in a living fossil, the Australian lungfish Neoceratodus forsteri
por: Bailes, Helena J, et al.
Publicado: (2007)

Does pharmaceutical advertising affect journal publication about dietary supplements?
por: Kemper, Kathi J, et al.
Publicado: (2008)

SOX4 can redirect TGF-β-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesis
por: Vervoort, Stephin J, et al.
Publicado: (2018)

In Vitro Evaluation of Spider Silk Meshes as a Potential Biomaterial for Bladder Reconstruction
por: Steins, Anne, et al.
Publicado: (2015)

Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome
por: Tufegdzic Vidakovic, Ana, et al.
Publicado: (2015)

Autoimmune disease-associated gene expression is reduced by BET-inhibition
por: Peeters, Janneke G.C., et al.
Publicado: (2015)

Induction of autophagy does not alter the anti-tumor effects of HDAC inhibitors
por: Newbold, A, et al.
Publicado: (2012)

Epistatic interactions between mutations of TACI (TNFRSF13B) and TCF3 result in a severe primary immunodeficiency disorder and systemic lupus erythematosus
por: Ameratunga, Rohan, et al.
Publicado: (2017)

Plasma Cell Ontogeny Defined by Quantitative Changes in Blimp-1 Expression
por: Kallies, Axel, et al.
Publicado: (2004)

The anticancer effects of HDAC inhibitors require the immune system
por: West, Alison C, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_6n2qvhg6pf8b0ev9pehinfg19u