The potential of PARP inhibitors in targeted cancer therapy and immunotherapy

DNA damage response (DDR) deficiencies result in genome instability, which is one of the hallmarks of cancer. Poly (ADP-ribose) polymerase (PARP) enzymes take part in various DDR pathways, determining cell fate in the wake of DNA damage. PARPs are readily druggable and PARP inhibitors (PARPi) agains...

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Detalles Bibliográficos
Autores principales: Hunia, Jaromir, Gawalski, Karol, Szredzka, Aleksandra, Suskiewicz, Marcin J., Nowis, Dominika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751342/
https://www.ncbi.nlm.nih.gov/pubmed/36533080
http://dx.doi.org/10.3389/fmolb.2022.1073797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751342/
https://www.ncbi.nlm.nih.gov/pubmed/36533080
http://dx.doi.org/10.3389/fmolb.2022.1073797

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