Cargando…

Generation of multicellular tumor spheroids with micro-well array for anticancer drug combination screening based on a valuable biomarker of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a highly malignant tumor with a poor prognosis. More than 30% of patients with diagnosed HCC have abnormally high expression of fibroblast growth factor receptor 4 (FGFR4). Currently, clinical trials for a variety of FGFR4-specific inhibitors have started. However,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Qi, Liu, Juan, Yin, Wenzhen, Sun, Dawei, Man, Zhongsong, Jiang, Shangwei, Ran, Xiufeng, Su, Yuxin, Wang, Yunfang, Dong, Jiahong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751422/ https://www.ncbi.nlm.nih.gov/pubmed/36532586 http://dx.doi.org/10.3389/fbioe.2022.1087656

Ejemplares similares

Microfluidic Biofabrication of 3D Multicellular Spheroids by Modulation of Non-geometrical Parameters
por: Lopa, Silvia, et al.
Publicado: (2020)

Human Melanocyte-Derived Spheroids: A Precise Test System for Drug Screening and a Multicellular Unit for Tissue Engineering
por: Zurina, Irina M., et al.
Publicado: (2020)

Production of Fatty Acid-Derived Valuable Chemicals in Synthetic Microbes
por: Yu, Ai-Qun, et al.
Publicado: (2014)

A cytokine-induced spheroid-based in vitro model for studying osteoarthritis pathogenesis
por: Scalzone, Annachiara, et al.
Publicado: (2023)

Fruits By-Products – A Source of Valuable Active Principles. A Short Review
por: Fierascu, Radu C., et al.
Publicado: (2020)

Integration of Hydrogel Microparticles With Three-Dimensional Liver Progenitor Cell Spheroids
por: Gentile, Stefan D., et al.
Publicado: (2020)

Numerical Investigations of Hepatic Spheroids Metabolic Reactions in a Perfusion Bioreactor
por: Sharifi, Fatemeh, et al.
Publicado: (2019)

Hybrid Bioprinting of Chondrogenically Induced Human Mesenchymal Stem Cell Spheroids
por: De Moor, Lise, et al.
Publicado: (2020)

Integration of Engineered “Spark-Cell” Spheroids for Optical Pacing of Cardiac Tissue
por: Chua, Christianne J., et al.
Publicado: (2021)

Oriented Neural Spheroid Formation and Differentiation of Neural Stem Cells Guided by Anisotropic Inverse Opals
por: Xia, Lin, et al.
Publicado: (2020)

Evidence-Based Network Modelling to Simulate Nucleus Pulposus Multicellular Activity in Different Nutritional and Pro-Inflammatory Environments
por: Baumgartner, L., et al.
Publicado: (2021)

Is the Pelvis-Thorax Coordination a Valuable Outcome Instrument to Assess Patients With Hip Osteoarthritis?
por: Moissenet, Florent, et al.
Publicado: (2020)

Comparison of Three Xylose Pathways in Pseudomonas putida KT2440 for the Synthesis of Valuable Products
por: Bator, Isabel, et al.
Publicado: (2020)

Editorial: Methods in industrial biotechnology and bioprocess engineering—Microalgae as a source of valuable compounds
por: Sivaramakrishnan, Ramachandran, et al.
Publicado: (2023)

Bioprinting Cell- and Spheroid-Laden Protein-Engineered Hydrogels as Tissue-on-Chip Platforms
por: Duarte Campos, Daniela F., et al.
Publicado: (2020)

Hypoxia Onset in Mesenchymal Stem Cell Spheroids: Monitoring With Hypoxia Reporter Cells
por: Schmitz, Carola, et al.
Publicado: (2021)

Dynamic Culture of Mesenchymal Stromal/Stem Cell Spheroids and Secretion of Paracrine Factors
por: Fuentes, Paloma, et al.
Publicado: (2022)

Tumor-Acidity Responsive Polymeric Nanoparticles for Targeting Delivery of Angiogenesis Inhibitor for Enhanced Antitumor Efficacy With Decreased Toxicity
por: Cong, Xiufeng, et al.
Publicado: (2021)

Recent Progress in Bio-Responsive Drug Delivery Systems for Tumor Therapy
por: Cong, Xiufeng, et al.
Publicado: (2022)

Xeno-Free Spheroids of Human Gingiva-Derived Progenitor Cells for Bone Tissue Engineering
por: Shanbhag, Siddharth, et al.
Publicado: (2020)

A platform for automated and label-free monitoring of morphological features and kinetics of spheroid fusion
por: Deckers, Thomas, et al.
Publicado: (2022)

Corrigendum: Hypoxia Onset in Mesenchymal Stem Cell Spheroids: Monitoring With Hypoxia Reporter Cells
por: Schmitz, Carola, et al.
Publicado: (2022)

Multi-Cell Type Glioblastoma Tumor Spheroids for Evaluating Sub-Population-Specific Drug Response
por: Sivakumar, Hemamylammal, et al.
Publicado: (2020)

Ultra-Thin Porous PDLLA Films Promote Generation, Maintenance, and Viability of Stem Cell Spheroids
por: Tsai, Ya An, et al.
Publicado: (2021)

Establishment of Functional Liver Spheroids From Human Hepatocyte-Derived Liver Progenitor-Like Cells for Cell Therapy
por: Liu, Wen-Ming, et al.
Publicado: (2021)

A Novel Scaffold-Based Hybrid Multicellular Model for Pancreatic Ductal Adenocarcinoma—Toward a Better Mimicry of the in vivo Tumor Microenvironment
por: Gupta, Priyanka, et al.
Publicado: (2020)

Spheroid Coculture of Human Gingiva-Derived Progenitor Cells With Endothelial Cells in Modified Platelet Lysate Hydrogels
por: Shanbhag, Siddharth, et al.
Publicado: (2021)

Bioreactor Suspension Culture: Differentiation and Production of Cardiomyocyte Spheroids From Human Induced Pluripotent Stem Cells
por: Kahn-Krell, Asher, et al.
Publicado: (2021)

Pulsed Electric Fields-Assisted Extraction of Valuable Compounds From Arthrospira Platensis: Effect of Pulse Polarity and Mild Heating
por: Carullo, Daniele, et al.
Publicado: (2020)

3D bioprinting of dECM-incorporated hepatocyte spheroid for simultaneous promotion of cell-cell and -ECM interactions
por: Kim, Min Kyeong, et al.
Publicado: (2023)

Prediction of Anticancer Peptides Using a Low-Dimensional Feature Model
por: Li, Qingwen, et al.
Publicado: (2020)

Computational Modelling and Big Data Analysis of Flow and Drug Transport in Microfluidic Systems: A Spheroid-on-a-Chip Study
por: Kheiri, Sina, et al.
Publicado: (2021)

Single neurons on microelectrode array chip: manipulation and analyses
por: Zhang, Hongyong, et al.
Publicado: (2023)

Dynamic TF-lncRNA Regulatory Networks Revealed Prognostic Signatures in the Development of Ovarian Cancer
por: Guo, Qiuyan, et al.
Publicado: (2020)

Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword
por: Wang, Jie, et al.
Publicado: (2021)

A Shaking-Culture Method for Generating Bone Marrow Derived Mesenchymal Stromal/Stem Cell-Spheroids With Enhanced Multipotency in vitro
por: Niibe, Kunimichi, et al.
Publicado: (2020)

Kinetics of Nanomedicine in Tumor Spheroid as an In Vitro Model System for Efficient Tumor-Targeted Drug Delivery With Insights From Mathematical Models
por: Roy, Sayoni Maitra, et al.
Publicado: (2021)

Facile preparation of toluidine blue-loaded DNA nanogels for anticancer photodynamic therapy
por: Guo, Hua, et al.
Publicado: (2023)

Heterotypic Tumor Spheroids in Agitation-Based Cultures: A Scaffold-Free Cell Model That Sustains Long-Term Survival of Endothelial Cells
por: Franchi-Mendes, Teresa, et al.
Publicado: (2021)

A three-dimensional actively spreading bone repair material based on cell spheroids can facilitate the preservation of tooth extraction sockets
por: Guo, Xinwei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bggql3vcpm8d8kn3t9s4jnp9k3