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Sex‐Specific Differences in G(s)α‐Mediated Signaling Downstream of PTH1R Activation by Abaloparatide in Bone

Teriparatide, recombinant parathyroid hormone (PTH[1‐34]), and abaloparatide, an analogue of PTH related‐peptide (PTHrP[1‐34]), are both anabolic medications for osteoporosis that target the PTH receptor PTH1R. PTH1R is a G protein–coupled receptor, and the stimulatory Gs protein is an important med...

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Detalles Bibliográficos
Autores principales: Swami, Srilatha, Johnson, Joshua, Vecchi, Lawrence A, Kim, Matthew J, Lanske, Beate, Johnson, Rachelle W, Wu, Joy Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751656/
https://www.ncbi.nlm.nih.gov/pubmed/36530190
http://dx.doi.org/10.1002/jbm4.10695