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Vaccination with Designed Neopeptides Induces Intratumoral, Cross-reactive CD4(+) T-cell Responses in Glioblastoma
PURPOSE: The low mutational load of some cancers is considered one reason for the difficulty to develop effective tumor vaccines. To overcome this problem, we developed a strategy to design neopeptides through single amino acid mutations to enhance their immunogenicity. EXPERIMENTAL DESIGN: Exome an...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for Cancer Research
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751771/ https://www.ncbi.nlm.nih.gov/pubmed/36228153 http://dx.doi.org/10.1158/1078-0432.CCR-22-1741 |