Vaccination with Designed Neopeptides Induces Intratumoral, Cross-reactive CD4(+) T-cell Responses in Glioblastoma

PURPOSE: The low mutational load of some cancers is considered one reason for the difficulty to develop effective tumor vaccines. To overcome this problem, we developed a strategy to design neopeptides through single amino acid mutations to enhance their immunogenicity. EXPERIMENTAL DESIGN: Exome an...

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Detalles Bibliográficos
Autores principales: Wang, Jian, Weiss, Tobias, Neidert, Marian C., Toussaint, Nora C., Naghavian, Reza, Sellés Moreno, Carla, Foege, Magdalena, Tomas Ojer, Paula, Medici, Gioele, Jelcic, Ivan, Schulz, Daniel, Rushing, Elisabeth, Dettwiler, Susanne, Schrörs, Barbara, Shin, Joo Heon, McKay, Ron, Wu, Catherine J., Lutterotti, Andreas, Sospedra, Mireia, Moch, Holger, Greiner, Erich F., Bodenmiller, Bernd, Regli, Luca, Weller, Michael, Roth, Patrick, Martin, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Precision Medicine and Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751771/
https://www.ncbi.nlm.nih.gov/pubmed/36228153
http://dx.doi.org/10.1158/1078-0432.CCR-22-1741

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