153. Molnupiravir Exhibits a High Barrier to the Development of SARS-CoV-2 Resistance in vitro

BACKGROUND: Molnupiravir is an orally available prodrug of the antiviral nucleoside analog N-Hydroxycytidine (NHC). In preclinical studies NHC has shown broad-spectrum antiviral activity against multiple RNA viruses including SARS-CoV-2. Incorporation of NHC by viral polymerases impairs replication...

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Detalles Bibliográficos
Autores principales: Strizki, Julie, Murgolo, Nicholas, Gaspar, John, Howe, John, Hutchins, Beth, Mohri, Hiroshi, Ho, David D, Hazuda, Daria, Grobler, Jay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752128/
http://dx.doi.org/10.1093/ofid/ofac492.231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752128/
http://dx.doi.org/10.1093/ofid/ofac492.231

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