Lactate increases tumor malignancy by promoting tumor small extracellular vesicles production via the GPR81-cAMP-PKA-HIF-1α axis

Lactate and tumor cell-derived extracellular vesicles (TEVs) both contribute to tumor progression. However, it is still unclear whether lactate can accelerate tumor development by directly promoting TEV production. Here, we show that lactate decreases intracellular cAMP levels and subsequent PKA act...

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Detalles Bibliográficos
Autores principales: Luo, Man, Zhu, Junqi, Ren, Jie, Tong, Yuxiao, Wang, Limin, Ma, Shenglin, Wang, Jiaoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753130/
https://www.ncbi.nlm.nih.gov/pubmed/36531060
http://dx.doi.org/10.3389/fonc.2022.1036543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753130/
https://www.ncbi.nlm.nih.gov/pubmed/36531060
http://dx.doi.org/10.3389/fonc.2022.1036543

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