Cullin 2-RBX1 E3 ligase and USP2 regulate antithrombin ubiquitination and stability

Hemophilia A and B are congenital bleeding disorders caused by a deficiency in pro-coagulant factor VIII or IX that is treated by downregulation of antithrombin. However, the molecular mechanisms that regulate antithrombin expression remain poorly understood. Here, we identified Cullin 2 and USP2 (u...

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Detalles Bibliográficos
Autores principales: Xu, Dacai, Wu, Jiawen, Chen, Jinghong, Jiang, Liling, Chen, Juan, Bao, Wenhao, Chen, Xin, Yang, Qianqian, Zhang, Xiaolan, Yao, Leyi, Su, Huabo, Liu, Jinbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753150/
https://www.ncbi.nlm.nih.gov/pubmed/34324733
http://dx.doi.org/10.1096/fj.202001146RR

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753150/
https://www.ncbi.nlm.nih.gov/pubmed/34324733
http://dx.doi.org/10.1096/fj.202001146RR

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