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Cullin 2-RBX1 E3 ligase and USP2 regulate antithrombin ubiquitination and stability
Hemophilia A and B are congenital bleeding disorders caused by a deficiency in pro-coagulant factor VIII or IX that is treated by downregulation of antithrombin. However, the molecular mechanisms that regulate antithrombin expression remain poorly understood. Here, we identified Cullin 2 and USP2 (u...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753150/ https://www.ncbi.nlm.nih.gov/pubmed/34324733 http://dx.doi.org/10.1096/fj.202001146RR |