Predicting In Vitro and In Vivo Anti-SARS-CoV-2 Activities of Antivirals by Intracellular Bioavailability and Biochemical Activity

[Image: see text] Cellular drug response (concentration required for obtaining 50% of a maximum cellular effect, EC(50)) can be predicted by the intracellular bioavailability (F(ic)) and biochemical activity (half-maximal inhibitory concentration, IC(50)) of drugs. In an ideal model, the cellular ne...

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Detalles Bibliográficos
Autores principales: Zhang, Jinwen, He, Mingfeng, Xie, Qian, Su, Ailing, Yang, Kuangyang, Liu, Lichu, Liang, Jianhui, Li, Ziqi, Huang, Xiuxin, Hu, Jianshu, Liu, Qian, Song, Bing, Hu, Chun, Chen, Lei, Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753181/
https://www.ncbi.nlm.nih.gov/pubmed/36530252
http://dx.doi.org/10.1021/acsomega.2c05376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753181/
https://www.ncbi.nlm.nih.gov/pubmed/36530252
http://dx.doi.org/10.1021/acsomega.2c05376

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