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Predicting In Vitro and In Vivo Anti-SARS-CoV-2 Activities of Antivirals by Intracellular Bioavailability and Biochemical Activity
[Image: see text] Cellular drug response (concentration required for obtaining 50% of a maximum cellular effect, EC(50)) can be predicted by the intracellular bioavailability (F(ic)) and biochemical activity (half-maximal inhibitory concentration, IC(50)) of drugs. In an ideal model, the cellular ne...
Autores principales: | Zhang, Jinwen, He, Mingfeng, Xie, Qian, Su, Ailing, Yang, Kuangyang, Liu, Lichu, Liang, Jianhui, Li, Ziqi, Huang, Xiuxin, Hu, Jianshu, Liu, Qian, Song, Bing, Hu, Chun, Chen, Lei, Wang, Yan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753181/ https://www.ncbi.nlm.nih.gov/pubmed/36530252 http://dx.doi.org/10.1021/acsomega.2c05376 |
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