Exogenous 8-hydroxydeoxyguanosine attenuates doxorubicin-induced cardiotoxicity by decreasing pyroptosis in H9c2 cardiomyocytes

Doxorubicin (DOX), which is widely used in cancer treatment, can induce cardiomyopathy. One of the main mechanisms whereby DOX induces cardiotoxicity involves pyroptosis through the NLR family pyrin domain containing 3 (NLRP3) inflammasome and gasdermin D (GSDMD). Increased NAPDH oxidase (NOX) and o...

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Detalles Bibliográficos
Autores principales: Hwang, Soyoung, Kim, Se-Hee, Yoo, Kwai Han, Chung, Myung-Hee, Lee, Jin Woo, Son, Kuk Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753270/
https://www.ncbi.nlm.nih.gov/pubmed/36517746
http://dx.doi.org/10.1186/s12860-022-00454-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753270/
https://www.ncbi.nlm.nih.gov/pubmed/36517746
http://dx.doi.org/10.1186/s12860-022-00454-1

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