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Subcellular location of source proteins improves prediction of neoantigens for immunotherapy

Antigen presentation via the major histocompatibility complex (MHC) is essential for anti‐tumor immunity. However, the rules that determine which tumor‐derived peptides will be immunogenic are still incompletely understood. Here, we investigated whether constraints on peptide accessibility to the MH...

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Detalles Bibliográficos
Autores principales: Castro, Andrea, Kaabinejadian, Saghar, Yari, Hooman, Hildebrand, William, Zanetti, Maurizio, Carter, Hannah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753441/
https://www.ncbi.nlm.nih.gov/pubmed/36314681
http://dx.doi.org/10.15252/embj.2022111071