Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair

Lysosome integrity is essential for cell viability, and lesions in lysosome membranes are repaired by the ESCRT machinery. Here, we describe an additional mechanism for lysosome repair that is activated independently of ESCRT recruitment. Lipidomic analyses showed increases in lysosomal phosphatidyl...

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Detalles Bibliográficos
Autores principales: Radulovic, Maja, Wenzel, Eva Maria, Gilani, Sania, Holland, Lya KK, Lystad, Alf Håkon, Phuyal, Santosh, Olkkonen, Vesa M, Brech, Andreas, Jäättelä, Marja, Maeda, Kenji, Raiborg, Camilla, Stenmark, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753466/
https://www.ncbi.nlm.nih.gov/pubmed/36408828
http://dx.doi.org/10.15252/embj.2022112677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753466/
https://www.ncbi.nlm.nih.gov/pubmed/36408828
http://dx.doi.org/10.15252/embj.2022112677

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