Synthesis, Antitumor Activity, and In Silico Drug Design of New Thieno[2,3-d]Pyrimidine-4-One Derivatives as Nonclassical Lipophilic Dihydrofolate Reductase Inhibitors

[Image: see text] Synthesis of a new series of 20 compounds bearing the thieno[2,3-d]pyrimidine-4-one scaffold was achieved. The inhibitory activity of these compounds was performed over 60 cell lines of human tumor at single and five dose concentrations. Compounds 20, 22, and 23 exhibited potent gr...

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Detalles Bibliográficos
Autores principales: Abdelaziz, Ola A., El Husseiny, Walaa M., Selim, Khalid B., Eisa, Hassan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753513/
https://www.ncbi.nlm.nih.gov/pubmed/36530275
http://dx.doi.org/10.1021/acsomega.2c06078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753513/
https://www.ncbi.nlm.nih.gov/pubmed/36530275
http://dx.doi.org/10.1021/acsomega.2c06078

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