Cargando…

Multicomponent Synthesis of Diaminopurine and Guanine PNA’s Analogues Active against Influenza A Virus from Prebiotic Compounds

[Image: see text] Peptide nucleic acids (PNAs) play a key role in prebiotic chemistry as a chimera between RNA and proteins. We developed an alternative synthesis of bioactive PNA’s diaminopurine and guanine analogues from prebiotic compounds, such as aminomalononitrile (AMN), urea, and guanidine, u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bizzarri, Bruno Mattia, Fanelli, Angelica, Ciprini, Stefania, Giorgi, Alessandra, De Angelis, Marta, Fioravanti, Raoul, Nencioni, Lucia, Saladino, Raffaele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753540/ https://www.ncbi.nlm.nih.gov/pubmed/36530301 http://dx.doi.org/10.1021/acsomega.2c05754

Ejemplares similares

Aminomalononitrile inspired prebiotic chemistry as a novel multicomponent tool for the synthesis of imidazole and purine derivatives with anti-influenza A virus activity
por: Bizzarri, Bruno Mattia, et al.
Publicado: (2021)

2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions
por: Szabla, Rafał, et al.
Publicado: (2021)

Pyrene-modified PNAs: Stacking interactions and selective excimer emission in PNA(2)DNA triplexes
por: Manicardi, Alex, et al.
Publicado: (2014)

Synthesis and Biological Properties of Caffeic Acid-PNA Dimers Containing Guanine
por: Gaglione, Maria, et al.
Publicado: (2013)

Nanomechanics of negatively supercoiled diaminopurine-substituted DNA
por: Salerno, Domenico, et al.
Publicado: (2021)

(α,α-dimethyl)glycyl (dmg) PNAs: Achiral PNA analogs that form stronger hybrids with cDNA relative to isosequential RNA
por: Gourishankar, Aland, et al.
Publicado: (2012)

Tautomerism of Guanine Analogues
por: Štoček, Jakub Radek, et al.
Publicado: (2020)

A chemical synthesis of LNA-2,6-diaminopurine riboside, and the influence of 2′-O-methyl-2,6-diaminopurine and LNA-2,6-diaminopurine ribosides on the thermodynamic properties of 2′-O-methyl RNA/RNA heteroduplexes
por: Pasternak, Anna, et al.
Publicado: (2007)

Introducing PNAS Nexus
por: Nelson, Karen, et al.
Publicado: (2022)

Welcome, PNAS Nexus!
por: McNutt, Marcia
Publicado: (2022)

Meteorite-catalyzed intermolecular trans-glycosylation produces nucleosides under proton beam irradiation
por: Bizzarri, Bruno Mattia, et al.
Publicado: (2021)

A Global Scale Scenario for Prebiotic Chemistry: Silica-Based Self-Assembled Mineral Structures and Formamide
por: Saladino, Raffaele, et al.
Publicado: (2016)

Prebiotic Organic Chemistry of Formamide and the Origin of Life in Planetary Conditions: What We Know and What Is the Future
por: Bizzarri, Bruno Mattia, et al.
Publicado: (2021)

Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity
por: Zippilli, Claudio, et al.
Publicado: (2021)

Dendrimeric Structures in the Synthesis of Fine Chemicals
por: Bizzarri, Bruno Mattia, et al.
Publicado: (2021)

Happy first birthday, PNAS Nexus
Publicado: (2023)

CYTOLOGICAL STUDIES ON THE ANTIMETABOLITE ACTION OF 2,6-DIAMINOPURINE IN VICIA FABA ROOTS
por: Setterfield, George, et al.
Publicado: (1955)

2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations
por: Trzaska, Carole, et al.
Publicado: (2020)

System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2
por: Vicenti, Ilaria, et al.
Publicado: (2021)

PNAS establishes a Statistical Review Committee
por: Raftery, Adrian E., et al.
Publicado: (2023)

A Shared Prebiotic Formation of Neopterins and Guanine Nucleosides from Pyrimidine Bases
por: Menor‐Salván, César, et al.
Publicado: (2022)

Systematic Differences in Impact across Publication Tracks at PNAS
por: Rand, David G., et al.
Publicado: (2009)

Species-Selective Killing of Bacteria by Antimicrobial Peptide-PNAs
por: Mondhe, Madhav, et al.
Publicado: (2014)

PNAS rebrand: Improving accessibility in its many forms
por: Berenbaum, May R.
Publicado: (2022)

Correction to: Volume 2 Issue 1 of PNAS Nexus
Publicado: (2023)

Solid-Phase Synthesis of Difficult Purine-Rich PNAs through Selective Hmb Incorporation: Application to the Total Synthesis of Cell Penetrating Peptide-PNAs
por: Tailhades, Julien, et al.
Publicado: (2017)

Fluorogenic PNA probes
por: Vilaivan, Tirayut
Publicado: (2018)

Helix control in polymers: Case of peptide nucleic acids (PNAs)
por: Totsingan, Filbert, et al.
Publicado: (2012)

Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS)
por: Del Bene, Alessandra, et al.
Publicado: (2023)

The first crystal structures of RNA–PNA duplexes and a PNA-PNA duplex containing mismatches—toward anti-sense therapy against TREDs
por: Kiliszek, Agnieszka, et al.
Publicado: (2016)

Cladribine Analogues via O(6)-(Benzotriazolyl) Derivatives of Guanine Nucleosides
por: Satishkumar, Sakilam, et al.
Publicado: (2015)

The function of tcf3 in medaka embryos: efficient knockdown with pePNAs
por: Doenz, Gerlinde, et al.
Publicado: (2018)

Synthesis of PNA Oligoether Conjugates
por: Ghidini, Alice, et al.
Publicado: (2014)

Selective recognition of DNA from olive leaves and olive oil by PNA and modified-PNA microarrays
por: Rossi, Stefano, et al.
Publicado: (2012)

A Chemical Approach to Introduce 2,6-Diaminopurine and 2-Aminoadenine Conjugates into Oligonucleotides without Need for Protecting Groups
por: Madaoui, Mimouna, et al.
Publicado: (2022)

The Prevailing Catalytic Role of Meteorites in Formamide Prebiotic Processes
por: Saladino, Raffaele, et al.
Publicado: (2018)

Carbon nanotubes supported tyrosinase in the synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols with antiviral activity against DNA and RNA viruses
por: Botta, Giorgia, et al.
Publicado: (2015)

γ sulphate PNA (PNA S): Highly Selective DNA Binding Molecule Showing Promising Antigene Activity
por: Avitabile, Concetta, et al.
Publicado: (2012)

Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistry
por: Wiessler, Manfred, et al.
Publicado: (2010)

Evaluation of an antibody-PNA conjugate as a clearing agent for antibody-based PNA-mediated radionuclide pretargeting
por: Myrhammar, Anders, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mp61vnhr7afqb86adb6i0pio57