Targeting H3K27me3 demethylase to inhibit Shh signaling and cholesterol metabolism in medulloblastoma growth

Previously we uncovered the epigenetic regulation of medulloblastoma that low levels of H3K27me3 are required for Shh target gene expression and medulloblastoma growth. Since Jmjd3, an H3K27me3 demethylase, is responsible for maintaining low H3K27me3 at Shh target genes, targeting Jmjd3 could be an...

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Detalles Bibliográficos
Autores principales: Deng, Hongshi, Guo, Xueli, Feng, Na, Luo, Yi, Liu, Bei, Liu, Shuzhen, Wu, Jiang I., Shi, Xuanming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753684/
https://www.ncbi.nlm.nih.gov/pubmed/36531063
http://dx.doi.org/10.3389/fonc.2022.1057147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753684/
https://www.ncbi.nlm.nih.gov/pubmed/36531063
http://dx.doi.org/10.3389/fonc.2022.1057147

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